METTL7B Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 2 - 4 ug/mL, ICC: 2.5 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	MettL7B antibody was raised against a 13 amino acid peptide near the amino terminus of human MettL7B.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	methyltransferase like 7B
Database Link	NP_689850 Entrez Gene 71664 MouseEntrez Gene 196410 Human UniProt ID Q6UX53
Background	MettL7b belongs to the methyltransferase superfamily. It is a probable methyltransferase. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a donor to an acceptor. Often methylation occurs on nucleic bases in DNA or amino acids in protein structures. DNA methylation is often utilized to silence and regulate genes without changing the original DNA sequence. DNA methylation may be necessary for normal growth from embryonic stages in mammals. When mutant embryonic stem cells lacking the murine DNA methyltransferase gene were introduced to a germline of mice they caused a recessive lethal phenotype. Methylation may also be linked to cancer development as methylation of tumor suppressor genes promotes tumorgenesis and metastasis. This MettL7B antibody is predicted to not cross-react with MettL7A.
Synonyms	ALDI
Reference Data
Protein Families	Druggable Genome, Transmembrane

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