Angiotensin II Type 2 Receptor (AGTR2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, ICC/IF, IHC, WB
Recommend Dilution	WB: 1-4 µg/mL IHC-P: 1-4 µg/mL IHC-P/IF: 10-20 µg/mL ICC/IF: 5-20 µg/mL. Antibody validated: Western Blot in mouse and rat samples Immunohistochemistry in human and mouse samples Immunofluorescence in human and rat samples. All other applications and species not yet tested.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Anti-AGTR2 antibody (5393) was raised against a peptide corresponding to 16 amino acid synthetic peptide near the center of human AGTR2. The immunogen is located within amino acids 220-270 of AGTR2.
Isotype	IgG
Formulation	AGTR2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/mL
Purification	AGTR2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	AGTR2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Predicted Protein Size	Predicted: 41 kD Observed: 41 kD
Gene Name	angiotensin II receptor type 2
Database Link	NP_000677 Entrez Gene 11609 MouseEntrez Gene 24182 RatEntrez Gene 186 Human UniProt ID P50052
Background	AGTR2 Antibody: Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion that acts through at least two types of receptors, AGTR1 and AGTR2. It is an important effector controlling blood pressure and volume in the cardiovascular system and plays a major role in the development of the mammalian kidney and urinary tract. Like AGTR1, AGTR2 is a seven transmembrane G protein-coupled receptor (GPCR), but AGTR2 does not demonstrate most of the classic features of GPCR signaling. AGTR2 is involved in a wide range of activities, including the induction of neurite outgrowth and the inhibition of cellular proliferation, in addition to the known function of mediation of vasoconstriction.
Synonyms	AT2; ATGR2; MRX88
Note	Optimal dilutions for each application to be determined by the researcher.
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction, Renin-angiotensin system

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