VPS11 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Reactivity	Human, Mouse, Rat, Zebrafish, Bovine, X. tropicalis, Medaka fish
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region within amino acids 300 and 392 of VPS11 (Uniprot ID#Q9H270)
Isotype	IgG
Formulation	0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration	lot specific
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	108 kDa
Gene Name	VPS11, CORVET/HOPS core subunit
Database Link	NP_068375 Entrez Gene 71732 MouseEntrez Gene 315600 RatEntrez Gene 55823 Human UniProt ID Q9H270
Background	Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq]
Synonyms	END1; hVPS11; PEP5; RNF108
Note	Seq homology of immunogen across species: Mouse (100%), Rat (100%), Zebrafish (85%), Japanese Medaka (100%), Xenopus Tropicalis (92%), Bovine (100%)
Reference Data
Protein Families	Druggable Genome

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