Inhibin beta A (INHBA) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Reactivity	Human, Mouse, Rat, Feline, Pig, Chicken, Sheep, Bovine
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region within amino acids 362 and 426 of Inhibin beta A
Formulation	0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	47 kDa
Gene Name	inhibin beta A subunit
Database Link	NP_002183 Entrez Gene 16323 MouseEntrez Gene 29200 RatEntrez Gene 3624 Human UniProt ID P08476
Background	The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. Finally, it has been shown that the beta A subunit mRNA is identical to the erythroid differentiation factor subunit mRNA and that only one gene for this mRNA exists in the human genome. [provided by RefSeq]
Synonyms	EDF; FRP
Note	Seq homology of immunogen across species: Mouse (100%), Rat (100%), Cat (100%), Pig (100%), Chicken (100%), Sheep (100%), Bovine (100%)
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Cytokine-cytokine receptor interaction, TGF-beta signaling pathway

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