Protein C (PROC) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB:1:500-1:3000
Reactivity	Human, Dog
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant fragment corresponding to a region within amino acids 145 and 461 of Protein C (Uniprot ID#P04070)
Isotype	IgG
Formulation	0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration	lot specific
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	52 kDa
Gene Name	protein C, inactivator of coagulation factors Va and VIIIa
Database Link	NP_000303 Entrez Gene 476104 DogEntrez Gene 5624 Human UniProt ID P04070
Background	The PROC gene encodes protein C (EC 3.4.21.69), a vitamin K-dependent plasma glycoprotein that is a key component of the anticoagulant system. Protein C is cleaved to its activated form, 'activated protein C' (APC) on endothelial cells by the thrombin-thrombomodulin complex (MIM 176930; MIM 188040) and then acts as a serine protease to degrade the activated forms of coagulation factors V (F5; MIM 612309) and VIII (F8; see MIM 306700). Protein S (PROS1; MIM 176880), also a vitamin K-dependent plasma protein, functions as a cofactor to activated protein C. [supplied by OMIM]
Synonyms	APC; PC; PROC1; THPH3; THPH4
Note	Seq homology of immunogen across species: Dog (82%)
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Complement and coagulation cascades

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