Nefl Chicken Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:10,000, IF: 1:5,000
Reactivity	Rat
Host	Chicken
Clonality	Polyclonal
Immunogen	Preparation of bovine spinal cord NF-L
Isotype	IgY
Formulation	total IgY fraction in PBS + 10 mM NaN3.
Purification	Total IgY fraction
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	68 kDa
Gene Name	neurofilament, light polypeptide
Database Link	NP_113971 Entrez Gene 83613 Rat UniProt ID P19527
Background	Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq]
Synonyms	CMT1F; CMT2E; FLJ53642; neurofilament-light; NF-L; NF68; NFL
Reference Data

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