Stat5a Mouse Monoclonal Antibody [Clone ID: 5F6.F1]

Specifications

Product Data
Clone Name	5F6.F1
Applications	IF, IHC, WB
Recommend Dilution	ELISA: 1:20,000, WB: 1:500 - 1:2,000, IHC: 20-40 ug/ml, IF: 1:50-1:1000
Reactivity	Human, Mouse, Rat
Modifications	Phospho-specific
Host	Mouse
Clonality	Monoclonal
Immunogen	Anti-STAT5 phospho Y694 monoclonal antibody was produced by repeated immunizations with a synthetic peptide corresponding to residues surrounding Y694 of mouse STAT5a protein.
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	signal transducer and activator of transcription 5A
Database Link	NP_035618 Entrez Gene 6776 HumanEntrez Gene 24918 RatEntrez Gene 20850 Mouse UniProt ID P42230
Synonyms	MGF; STAT5
Note	Signal transducer and activator of transcription 5 (Stat5) belongs to a family of cytoplasmic transcription factors that can be activated (phosphorylated) by a cell surface receptor. Phosphorylation at Tyr694 is obligatory for Stat5 activation. Stat5 has two isoforms, Stat5a ?and Stat5β. Aberrant Stat5 activation has been implicated in the pathogenesis of chronic myelogenous leukemia, prostate and breast cancer and tumor metastasis. Stat5 is localized in the cytoplasm and upon phosphorylation at Y694 is translocated to the nucleus. Ideal for Cancer, Chromatin & Nuclear Signaling and Signal Transduction research.
Reference Data

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