ULK1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	ULK1 antibody was raised against a 16 amino acid peptide near the center of human ULK1 .
Formulation	ULK1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	ULK1 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 116 kDa; Observed: 105 kDa
Gene Name	unc-51 like autophagy activating kinase 1
Database Link	NP_003556 Entrez Gene 22241 MouseEntrez Gene 360827 RatEntrez Gene 8408 Human UniProt ID O75385
Background	ULK1 Antibody: ULK1, also known as ATG1, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK1 results in a severe defect in the autophagy pathway. ULK1 is highly conserved among eukaryotes, and are the Unc-51-like kinases, ULK1 and ULK2 in mammals. ULK1 is ubiquitously expressed and involved in autophagy in response to starvation. It is the target of the TOR kinase signaling pathway that regulates autophagy through the control of phosphorylation status of ATG13. ULK1 also plays a role early in neuronal differentiation.
Synonyms	ATG1; ATG1A; hATG1; UNC51; Unc51.1
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	mTOR signaling pathway, Regulation of autophagy

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