CBX4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	CBX4 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CBX4.
Isotype	IgG
Formulation	CBX4 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	CBX4 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	62 kDa
Gene Name	chromobox 4
Database Link	NP_003646 Entrez Gene 12418 MouseEntrez Gene 501403 RatEntrez Gene 8535 Human UniProt ID O00257
Background	CBX4 Antibody: Polycomb group (PcG) proteins are chromatin-associated proteins which are important for embryonic and adult stem cell self-renewal and maintenance. At least two distinct human PcG complexes have been identified. Polycomb repressive complex I (PRC1) contains CBX4/Pc2, HPH1 and RING domain-containing proteins (RING1, RING2 and BMI1). CBX4 (Chromobox protein homolog 4 or PC2), which functions as a transcriptional suppressor, is a candidate of KyoT2-binding proteins. It is a E3 SUMO-protein ligase which facilitates SUMO1 conjugation. Depletion of CBX4 results in decreased cellular resistance to ionizing radiation. CBX4 is directly involved in the cellular response to DNA damage.
Synonyms	NBP16; PC2
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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