RIP (RIPK1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	E, IHC
Recommend Dilution	IHC: 5 - 10 ug/ml. Peptide Elisa.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	RIP1 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human RIP1.
Isotype	IgG
Formulation	RIP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	RIP1 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	74 kDa
Gene Name	receptor interacting serine/threonine kinase 1
Database Link	NP_003795 Entrez Gene 8737 Human UniProt ID Q13546
Background	RIP1 Antibody: RIP1 (Receptor Interacting Protein), also known as RIPK1, is a crucial 74 kD adaptor kinase in several of stress-induced signaling pathways and on the crossroad of a cell’s decision to live or die. RIP1 contains an N-terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C-terminal region containing a death domain motif present in the Fas and TNFR1 intracellular domains. Full length RIP1 is important for signallling to NF-kappa-B, MAPKs and necrosis, whereas caspase-8 generates a C-terminal RIP1 cleavage fragment, promoting TNF-induced apoptosis. It is required for TNFRSF1A-mediated and TLR3-induced NF-kappa-B activation. RIP1-deficient mice fail to thrive, displaying extensive apoptosis in both lymphoid and adipose tissues and dying at 1-3 days of age.
Synonyms	RIP; RIP-1; RIP1
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	Apoptosis, Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway

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