N4BP1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 0.5 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	N4BP1 antibody was raised against a 18 amino acid synthetic peptide near the amino terminus of human N4BP1.
Isotype	IgG
Formulation	N4BP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	N4BP1 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	NEDD4 binding protein 1
Database Link	NP_694574 Entrez Gene 80750 MouseEntrez Gene 291921 RatEntrez Gene 9683 Human UniProt ID O75113
Background	N4BP1 Antibody: Nedd4-binding partner-1 (N4BP1) is a developmentally expressed protein interactor and monoubiquitylation substrate of Nedd4, a HECT domain-containing ubiquitin ligase that mediates ubiquitylation and proteasome degradation of target proteins and may have a fundamental role to play in embryonic processes. N4BP1 can undergo Nedd4-mediated polyubiquitylation and proteosomal degradation. N4BP1 also functions as a negative regulator of AIF4 (also known as ITCH or Atrophin-1), an E3-ubiquitin ligase, by interacting with the second WW domain of AIF4 and impairing ubiquitination of substrates.
Synonyms	FLJ31821; KIAA0615; MGC176730
Reference Data

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