TOX1 (TOX) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IF: 20 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	TOX antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human TOX.
Formulation	TOX Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	TOX Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	58 kDa
Gene Name	thymocyte selection associated high mobility group box
Database Link	NP_055544 Entrez Gene 9760 Human UniProt ID O94900
Background	TOX Antibody: TOX (thymocyte selection-associated high mobility group (HMG) box protein) is a member of the HMG box family of DNA-binding proteins and likely plays a role in the regulation of T-cell development. It is a 526 amino acid nuclear protein and the expression of TOX is upregulated by pre-T cell receptor (pre-TCR) and TCR activation in immature thymocytes. TOX-mediated positive selection is associated with up-regulation of RUNX3 and is calcineurin dependent. TOX-dependent transition to the CD4+CD8 stage is required for development of class II major histocompatibility complex-specific T cells.
Synonyms	TOX1
Reference Data
Protein Families	Transcription Factors

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