SIVA (SIVA1) Chicken Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse
Host	Chicken
Clonality	Polyclonal
Immunogen	SIVA antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human SIVA.
Formulation	SIVA Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	SIVA Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	SIVA1 apoptosis inducing factor
Database Link	NP_068355 Entrez Gene 10572 Human UniProt ID O15304
Background	SIVA Antibody: SIVA plays an important role in the apoptotic pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. SIVA is a small cysteine-rich protein with a unique N-terminal amphipathic helical region, a death domain homology region (DDHR) and a C-terminal cysteine-rich B-box-like or zinc-finger-like structure. The DDHR domain binds to CD27 and induces apoptosis in T cells through a caspase-dependent mitochondrial pathway. SIVA inhibits BCL2L1 isoform Bcl-xL anti-apoptotic activity and inhibits activation of NFκ-B and promotes T-cell receptor-mediated apoptosis. SIVA represents a potential therapeutic target for the treatment of neuronal cell death diseases.
Synonyms	CD27BP; SIVA; Siva-1; Siva-2
Reference Data

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