Lipin 1 (LPIN1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	LPIN1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human LPIN1.
Isotype	IgG
Formulation	LPIN Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	LPIN1 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 107 kDa; Observed: 125 kDa
Gene Name	lipin 1
Database Link	NP_001248357 Entrez Gene 23175 Human UniProt ID Q14693
Background	LPIN1 Antibody: LPIN1, also known as PAP1, is a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol (reviewed in 1). LPIN1 is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism (1,2). Mutations in LPIN1 are associated with metabolic diseases such as type 2 diabetes and recurrent acute myoglobinuria (3,4) and it is also a candidate for several human lipodystrophy syndromes (5).
Synonyms	PAP1
Reference Data

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