KPNA6 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	KPNA6 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of human KPNA6.
Isotype	IgG
Formulation	KPNA6 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	KPNA6 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	karyopherin subunit alpha 6
Database Link	NP_036448 Entrez Gene 16650 MouseEntrez Gene 362607 RatEntrez Gene 23633 Human UniProt ID O60684
Background	KPNA6 Antibody: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6. Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation. KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import.
Synonyms	IPOA7; KPNA7
Reference Data
Protein Families	Druggable Genome

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