ZNF521 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	ZNF521 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human ZNF521.
Isotype	IgG
Formulation	ZNF521 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	ZNF521 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	zinc finger protein 521
Database Link	NP_056276 Entrez Gene 25925 Human UniProt ID Q96K83
Background	ZNF521 Antibody: The zinc finger protein 521 (ZNF521) is a transcription factor containing an N-terminal transcriptional repressor motif and 30 zinc finger domains. It plays a role in both erythroid cell and osteoblast differentiation during development, inhibiting the activities of early B-cell factor 1 (EBF1) in erythroid cells and Runx2 in osteoblast precursors. ZFP521 binds to both Runx2 and histone deacetylase 3 (HDAC3), promotes their association and antagonizes Runx2 transcriptional activity in a HDAC3-dependent manner, thereby regulating osteoblast differentiation, skeletal development, and bone homeostasis.
Synonyms	EHZF; Evi3
Reference Data

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