TLX3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 0.5 - 1 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	TLX3 antibody was raised against a 16 amino acid peptide near the amino terminus of human TLX3.
Isotype	IgG
Formulation	TLX3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	TLX3 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Predicted Protein Size	Predicted: 32 kDa; Observed: 30 kDa
Gene Name	T-cell leukemia homeobox 3
Database Link	NP_066305 Entrez Gene 27140 MouseEntrez Gene 497881 RatEntrez Gene 30012 Human UniProt ID O43711
Background	TLX3 Antibody: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX3, also known as homeobox11-like1 (HOX11L2), is a DNA-binding nuclear transcription factor that is expressed in a subset of the primary sensory nervous system. TLX3, along with the related TLX1, is a selector transcription factor that promotes an excitatory glutamatergic neuronal phenotype over an inhibitory GABAergic phenotype opposing LBX1 signals during dorsal spinal cord development. Chromosomal translocations of the TLX3 gene have been shown to result in some forms of T-cell acute lymphoblastic leukemia (T-ALL).
Synonyms	HOX11L2; RNX
Reference Data
Protein Families	Transcription Factors

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