BANP Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	BANP antibody was raised against a 14 amino acid synthetic peptide near the center of human BANP.
Isotype	IgG
Formulation	BANP Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	BANP Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	BTG3 associated nuclear protein
Database Link	NP_001167014 Entrez Gene 54971 Human UniProt ID Q8N9N5
Background	BANP Antibody: BANP was initially identified as a binding protein to BTG3 in a yeast two-hybrid screen. BANP acts as a tumor suppressor by stabilizing p53 expression and leading to cell cycle arrest. p53 in turn binds to upstream elements of the BANP promoter, thereby forming a feedback loop. BANP is down-regulated in advanced stages of human breast cancer, and its overexpression in breast cancer cell lines inhibits their ability to metastasize by modulating TGF-beta signaling. Furthermore, BANP can modulate NF-κB transactivation and can inhibit tumorigenesis by regulating NF-κB target genes. Recent experiments have shown that BANP can also repress HIV-1 LTR mediated transcription by tethering the LTR matrix attachment region to nuclear matrix.
Synonyms	BEND1; SMAR1; SMARBP1
Reference Data

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