PIWIL2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	PIWI-L2 antibody was raised against a 17 amino acid synthetic peptide near the center of human PIWI-L2.
Formulation	PIWI-L2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	PIWI-L2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	piwi like RNA-mediated gene silencing 2
Database Link	NP_001129193 Entrez Gene 57746 MouseEntrez Gene 55124 Human UniProt ID Q8TC59
Background	PIWI-L2 Antibody: PIWI-L2 is a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that are crucial for the biogenesis and function of small non-coding RNAs and play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. PIWI-L2 has been implicated in multiple roles including stem cell self-renewal and is highly expressed in many breast cancers. In these tumors, PIWI-L2 silences the expression of STAT3, a regulator of Bcl-XL and cyclin D1, allowing the proliferation and survival of breast cancer stem cells. Recent studies have shown that overexpression of PIWI-like proteins are potential biomarkers for colon and other cancers.
Synonyms	CT80; HILI; mili; PIWIL1L
Reference Data
Protein Pathways	Dorso-ventral axis formation

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