DDX60 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	DDX60 antibody was raised against a 17 amino acid synthetic peptide near the center of human DDX60.
Isotype	IgG
Formulation	DDX60 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	DDX60 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	188 kDa
Gene Name	DEXD/H-box helicase 60
Database Link	NP_060101 Entrez Gene 234311 MouseEntrez Gene 100360801 RatEntrez Gene 55601 Human UniProt ID Q8IY21
Background	DDX60 Antibody: DDX60 is a DEXD/H Box RNA helicase and the human homolog of the S. cerevisiae Ski2, a cofactor of RNA exosome. Expression of DDX60 increases after viral infection and binds to endogenous RIG-I, a cytoplasmic viral RNA sensor, as well as other RIG-I-like receptors such as MDA5 and LGP2. These proteins activate TBK1 and IKK-e, signaling IRF3 and NF-kB-responsive genes in the innate immune response pathway. DDX60 is required for the RIG-I- or MDA5-dependent response to viral infection, but is dispensable for TLR3-mediated signaling.
Synonyms	FLJ10787; FLJ20035
Reference Data

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