RNF20 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	RNF20 antibody was raised against a 19 amino acid peptide near the amino terminus of human RNF20.
Isotype	IgG
Formulation	RNF20 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	RNF20 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 99, 107 kDa; Observed: 100, 110 kDa
Gene Name	ring finger protein 20
Database Link	NP_062538 Entrez Gene 109331 MouseEntrez Gene 56254 Human UniProt ID Q5VTR2
Background	RNF20 Antibody: RNF20 is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. RNF20 selectively suppresses the expression of some genes such as several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). In contrast, RNF20 also positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. Together with the deubiquitinase USP44, RNF20 regulates stem cell differentiation by modulating H2B monoubiquitination.
Synonyms	BRE1; BRE1A; hBRE1
Reference Data
Protein Families	Druggable Genome

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