HHATL Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 2.5 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	HHATL antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human HHATL.
Isotype	IgG
Formulation	HHATL Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	HHATL Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	hedgehog acyltransferase-like
Database Link	NP_065758 Entrez Gene 74770 MouseEntrez Gene 301073 RatEntrez Gene 57467 Human UniProt ID Q9HCP6
Background	HHATL Antibody: The Protein-cysteine N-palmitoyltransferase HHAT-like protein (HHATL), also known at the mammalian glycerol uptake/transporter 1 (Gup1) is a homolog of the S. cerevisiae Gup1. It is an endoplasmic reticulum (ER) membrane protein that co-localizes with the mammalian hedgehog acyltransferse Skn and interferes with its N-terminal palmitoylation of Sonic hedgehog (SHH), suggesting that HHATL acts as a negative regulator for N-terminal palmitoylation of SHH. HHATL is highly expressed in normal skin, but becomes down-regulated in skin squamous cell carcinoma, suggesting it may play a role in its development.
Synonyms	C3orf3; GUP1; MBOAT3; MSTP002; OACT3
Reference Data
Protein Families	Transmembrane

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