FOXRED2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL, IF: 20 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	FOXRED2 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human FOXRED2.
Isotype	IgG
Formulation	FOXRED2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	FOXRED2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	FAD dependent oxidoreductase domain containing 2
Database Link	NP_001095841 Entrez Gene 80020 Human UniProt ID Q8IWF2
Background	FOXRED2 Antibody: FOXRED2, also known as ERFAD, is an endoplasmic reticulum (ER) luminal flavoprotein which may function in ER associated degradation (ERAD). It has been proposed to bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation. Upon knockdown of FOXRED2, the degradation of the ERAD model substrate ribophorin 332 is delayed, and the overall level of polyubiquitinated cellular proteins is decreased. Defects in the related protein FOXRED1 are a cause of mitochondrial complex I deficiency (MT-C1D), suggesting the FOXRED2 may also play a role in MT-C1D.
Synonyms	ERFAD
Reference Data
Protein Families	Druggable Genome

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