RC3H1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Rabbit polyclonal RC3H1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human RC3H1.
Isotype	IgG
Formulation	RC3H1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	RC3H1 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	125 kDa
Gene Name	ring finger and CCCH-type domains 1
Database Link	NP_742068 Entrez Gene 381305 MouseEntrez Gene 680586 RatEntrez Gene 149041 Human UniProt ID Q5TC82
Background	RC3H1 Antibody: The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING type ubiquitin ligase protein family whose M199R mutation leads to the excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, a strain with excessive IL-21 production and high titers of autoantibodies. The complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity in RC3H1-null mice, suggesting that the mutant RC3H1 is more disruptive to the immune system than its complete loss.
Synonyms	RNF198; ROQUIN
Reference Data
Protein Families	Druggable Genome

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