CCDC141 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	CCDC141 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CCDC141.
Isotype	IgG
Formulation	CCDC141 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	CCDC141 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	coiled-coil domain containing 141
Database Link	NP_775919 Entrez Gene 545428 MouseEntrez Gene 285025 Human UniProt ID Q6ZP82
Background	CCDC141 Antibody: Coiled-coil domain-containing protein 141 (CCDC141), also known as CAMDI, is a recently identified disrupted in schizophrenia 1 (DISC1)-binding protein that also associates with myosin II. CCDC141 preferentially associates with phosphomyosin II and causes an accumulation of phosphomyosin II at the centrosome in a DISC1-dependent manner. Knockdown of CCDC141 expression by RNAi led to severely impaired radial migration with disoriented chromosomes, suggesting that CCDC141 is required for radial migration through DISC1 and myosin II-mediated centrosome positioning during neuronal development.
Synonyms	CAMDI
Reference Data

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