NSE2 (NSMCE2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 0.5 - 1 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	MMS21 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human MMS21.
Isotype	IgG
Formulation	MMS21 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	MMS21 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
Database Link	NP_775956 Entrez Gene 68501 MouseEntrez Gene 299957 RatEntrez Gene 286053 Human UniProt ID Q96MF7
Background	MMS21 Antibody: MMS21, also known as NSE2, is a SUMO ligase that in combination with the SMC5/6 complex is required for the prevention of DNA damage induced apoptosis by facilitating DNA repair in human cells. MMS21-dependent sumoylation is integral and important to the cohesion mechanism and mitotic progression; this function appears to be independent of SMC6. MMS21 mediates SUMO attachment to various proteins such as SMC6L1 and TRAX, and possibly the cohesin components RAD21 and STAG2.
Synonyms	C8orf36; MMS21; NSE2; ZMIZ7
Reference Data

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