TSH Receptor (TSHR) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 21-253 amino acids of human thyroid stimulating hormone receptor
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	thyroid stimulating hormone receptor
Database Link	NP_000360 Entrez Gene 7253 Human UniProt ID P16473
Background	The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin; and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
Synonyms	CHNG1; hTSHR-I; LGR3
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Autoimmune thyroid disease, Neuroactive ligand-receptor interaction

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