Pleiotrophin (PTN) Rabbit Polyclonal Antibody
CAT＃: TA321534S
Anti-PTN Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1280.00
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CNY 300.00
CNY 1430.00
Specifications
| Product Data | |
| Applications | WB |
| Recommend Dilution | WB: 500-2000 WB positive control: Human colon cancer tissue |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 33-47 amino acids of human pleiotrophin |
| Isotype | IgG |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 19 kDa |
| Gene Name | pleiotrophin |
| Database Link | |
| Background | Pleiotrophin?(PTN) also known as?heparin-binding brain mitogen?(HBBM) or?heparin-binding growth factor 8?(HBGF-8) or?neurite growth-promoting factor 1?(NEGF1) or?heparin affinity regulatory peptide?(HARP) or?heparin binding growth associated molecule?(HB-GAM) is a?protein?that in humans is encoded by the?PTNgene.?Pleiotrophin is an 18-kDa?growth factor?that has a high affinity for?heparin. It is structurally related to?midkine?and?retinoic acid induced heparin-binding protein. Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts; epithelial; and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation; an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. |
| Synonyms | HARP; HBGF8; HBNF; NEGF1 |
| Reference Data | |
| Protein Families | Druggable Genome, Phosphatase, Secreted Protein, Transmembrane |
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