TRAF2 Rabbit Polyclonal Antibody

CAT#: TA321888

Anti-TRAF2 Rabbit Polyclonal Antibody

Size: 25 ul 100 ul



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CNY 1,999.00

CNY 3,280.00


货期*
2周

规格
    • 100 ul

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经常一起买 (4)
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Recombinant protein of human TNF receptor-associated factor 2 (TRAF2), 20 µg
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Recombinant protein of human TNF receptor-associated factor 2 (TRAF2), 100 µg
    • 100 ug

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Specifications

Product Data
Applications IHC, WB
Recommend Dilution WB: 200-1000
WB positive control: Human normal liver tissue
IHC: 25-100
Positive control: Human lung cancer
Predicted cell location: Cytoplasm
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Fusion protein corresponding to a region derived from 351-496 amino acids of human TNF receptor-associated factor 2
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration lot specific
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name TNF receptor associated factor 2
Background The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with; and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors; and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs); and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD; a TNF receptor associated apoptotic signal transducer; ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1; an apoptosis inhibitor possessing ubiquitin ligase activity; can unbiquitinate and induce the degradation of this protein; and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene; but the biological validity of only one transcript has been determined.
Synonyms MGC:45012; TRAP; TRAP3
Reference Data
Protein Families Druggable Genome
Protein Pathways Adipocytokine signaling pathway, Apoptosis, MAPK signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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