Agrin (AGRN) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human esophagus cancer Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 74-84 amino acids of human agrin
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	agrin
Database Link	NP_940978 Entrez Gene 375790 Human UniProt ID O00468
Background	This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ); as identified in mouse knock-out studies. The encoded protein contains several laminin G; Kazal type serine protease inhibitor; and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles; a mutation in this gene was found.
Synonyms	CMS8; CMSPPD
Reference Data
Protein Pathways	ECM-receptor interaction

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