ADAMTS10 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 1047-1074 amino acids of human ADAM metallopeptidase with thrombospondin type 1 motif, 10
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	ADAM metallopeptidase with thrombospondin type 1 motif 10
Database Link	NP_112219 Entrez Gene 224697 MouseEntrez Gene 81794 Human UniProt ID Q9H324
Background	This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization; coagulation; inflammation; arthritis; angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin; lens; and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.
Synonyms	ADAM-TS10; ADAMTS-10; WMS; WMS1
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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