iASPP (PPP1R13L) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: MCF7 and hela cells IHC: 50-200 Positive control: Human colon cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 781-797 amino acids of Human protein phosphatase 1, regulatory subunit 13 like
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	89 kDa
Gene Name	protein phosphatase 1 regulatory subunit 13 like
Database Link	NP_006654 Entrez Gene 333654 MouseEntrez Gene 10848 Human UniProt ID Q8WUF5
Background	RelA-associated inhibitor is a protein that in humans is encoded by the PPP1R13L gene. Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function; possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2; and therefore suppressing the subsequent activation of apoptosis. Interacts with RELA NF-kappa-B subunit and with SP1 via its C-terminus part. Interacts with p53/TP53; TP63 and TP73.
Synonyms	IASPP; NKIP1; RAI; RAI4
Reference Data
Protein Families	Transcription Factors

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