NGAL (LCN2) Rabbit Polyclonal Antibody
CAT＃: TA322583S
Anti-LCN2 Rabbit Polyclonal Antibody
Size: 100 ul
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Specifications
| Product Data | |
| Applications | IHC, WB |
| Recommend Dilution | WB: 1000-5000 WB positive control: Human liver cancer tissue IHC: 50-200 Positive control: Human breast cancer Predicted cell location: Cytoplasm |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide peptide corresponding to a region derived from 60-73 amino acids of human lipocalin 2 |
| Isotype | IgG |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 23 kDa |
| Gene Name | lipocalin 2 |
| Database Link | |
| Background | Iron-trafficking protein involved in multiple processes such as apoptosis; innate immunity and renal development. Binds iron through association with 2;5-dihydroxybenzoic acid (2;5-DHBA); a siderophore that shares structural similarities with bacterial enterobactin; and delivers or removes iron from the cell; depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor; leading to release of iron and subsequent increase of intracellular iron concentration. In contrast; association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore; iron chelation and iron transfer to the extracellular medium; thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis; while iron-free form decreases intracellular iron levels; inducing expression of the proapoptotic protein BCL2L11/BIM; resulting in apoptosis. Involved in innate immunity; possibly by sequestrating iron; leading to limit bacterial growth. |
| Synonyms | 24p3; MSFI; NGAL |
| Reference Data | |
| Protein Families | Secreted Protein |
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