RHOB Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1000-2000 WB positive control: Mouse brain and fetal brain tissue
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 179-188 amino acids of Human Ras homolog family member B
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	22 kDa
Gene Name	ras homolog family member B
Database Link	NP_004031 Entrez Gene 11852 MouseEntrez Gene 64373 RatEntrez Gene 388 Human UniProt ID P62745
Background	Ras homolog gene family; member B; also known as RHOB; is a protein which in humans is encoded by the RHOB gene.RHOB is a member of the Rho GTP-binding protein family.Mediates apoptosis in neoplastically transformed cells after DNA damage. It is not necessary for development but affects cell adhesion and growth factor signaling in transformed cells. It plays a negative role in tumorigenesis as deletion causes tumor formation. It involved in intracellular protein trafficking of a number of proteins; and serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.
Synonyms	ARH6; ARHB; MST081; MSTP081; RHOH6
Reference Data
Protein Families	Druggable Genome

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