TIMP1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 15-50 Positive control: Human cervical cancer Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 24-207 amino acids of human TIMP metallopeptidase inhibitor 1
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	TIMP metallopeptidase inhibitor 1
Database Link	NP_003245 Entrez Gene 7076 Human UniProt ID P01033
Background	This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs); a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs; the encoded protein is able to promote cell proliferation in a wide range of cell types; and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition; the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.
Synonyms	CLGI; EPA; EPO; HCI; TIMP; TIMP-1
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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