LRPAP1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: 293T cells and fetal kidney tissue IHC: 50-200 Positive control: Human colon cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 344-357 amino acids of Human low density lipoprotein receptor-related protein associated protein 1
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	41 kDa
Gene Name	LDL receptor related protein associated protein 1
Database Link	NP_002328 Entrez Gene 16976 MouseEntrez Gene 116565 RatEntrez Gene 4043 Human UniProt ID P30533
Background	Low density lipoprotein receptor-related protein associated protein 1?also known as?LRPAP1?or?RAP?is a chaperone?protein?which in humans is encoded by the LRPAP1?gene. LRPAP1 is involved with trafficking of certain members of the LDL receptor family including LRP1 and LRP2. It is a glycoprotein that binds to the alpha-2-macroglobulin receptor; as well as to other members of the low density lipoprotein receptor family. It acts to inhibit the binding of all know ligands for these receptors; and may prevent receptor aggregation and degradation in the endoplasmic reticulum; thereby acting as a molecular chaperone. It may be under the regulatory control of calmodulin; since it is able to bind calmodulin and be phosphorylated by calmodulin-dependent kinase II.
Synonyms	A2MRAP; A2RAP; alpha-2-MRAP; HBP44; MRAP; MYP23; RAP
Reference Data
Protein Families	Druggable Genome, Transmembrane

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