IDE Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: K562 cells IHC: 10-50 Positive control: Human colon cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a C terminal 300 amino acids of human insulin-degrading enzyme
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	118 kDa
Gene Name	insulin degrading enzyme
Database Link	NP_001159418 Entrez Gene 15925 MouseEntrez Gene 25700 RatEntrez Gene 3416 Human UniProt ID P14735
Background	This gene encodes a zinc metallopeptidase that degrades intracellular insulin; and thereby terminates insulins activity; as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon; amylin; bradykinin; and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space; cell membrane; peroxisome; and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.
Synonyms	INSULYSIN
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Alzheimer's disease

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