Frizzled 6 (FZD6) Rabbit Polyclonal Antibody
CAT＃: TA324004S
Anti-FZD6 Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1280.00
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CNY 300.00
CNY 1430.00
CNY 3080.00
Specifications
| Product Data | |
| Applications | IHC |
| Recommend Dilution | IHC: 100-300 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 47-60 amino acids of human frizzled family receptor 6 |
| Isotype | IgG |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Gene Name | frizzled class receptor 6 |
| Database Link | |
| Background | This gene represents a member of the 'frizzled' gene family; which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide; a cysteine-rich domain in the N-terminal extracellular region; and seven transmembrane domains; but unlike other family members; this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade; thereby inhibiting the processes that trigger oncogenic transformation; cell proliferation; and inhibition of apoptosis. Alternative splicing results in multiple transcript variants; some of which do not encode a protein with a predicted signal peptide. |
| Synonyms | FZ-6; FZ6; HFZ6; NDNC10 |
| Reference Data | |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways | Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway |
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