Tissue Factor (F3) Rabbit Polyclonal Antibody
CAT＃: TA324022S
Anti-F3 Rabbit Polyclonal Antibody
Size: 100 ul
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Specifications
| Product Data | |
| Applications | IHC, WB |
| Recommend Dilution | WB: 200-1000 WB positive control: Human fetal lung tissue IHC: 25-100 Positive control: Human gasrtic cancer Predicted cell location: Membrane |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Fusion protein corresponding to a region derived from 33-251 amino acids of human coagulation factor III (thromboplastin, tissue factor) |
| Isotype | IgG |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 33 kDa |
| Gene Name | coagulation factor III, tissue factor |
| Database Link | |
| Background | This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades; and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades; which circulate as nonfunctional precursors; this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular; transmembrane; and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants. |
| Synonyms | CD142; TF; TFA |
| Reference Data | |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Complement and coagulation cascades |
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