Hsp47 (SERPINH1) Mouse Monoclonal Antibody [Clone ID: 1C4-1A6]

Specifications

Product Data
Clone Name	1C4-1A6
Applications	WB
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human Hsp47, full length
Isotype	IgG1, kappa
Formulation	PBS pH7.4, 50% glyercol and 0.09% sodium azide
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	serpin family H member 1
Database Link	NP_001226 Entrez Gene 871 Human UniProt ID P50454
Background	Versican (chondroitin sulfate proteoglycan 2) is a large extracellular matrix proteoglycan involved in cell growth and differentiation. Important as a structural molecule, versican creates loose and hydrated matrices during key events in development and disease. The protein contains hyaluronic acid and glycosminoglycan-binding domains, epidermal growth factor-like repeats, a Lectinlike sequence and a complement regulatory protein-like domain. Splice variants differ greatly in length and degree of modification by glycoaminoglycan chains. Accumulation around smooth muscle cells in lesions of athero-sclerosis suggests a role for versican in atherogenesis. Versican, differentially expressed in human melanoma, plays a role in tumor development and may be a reliable marker for clinical diagnosis. The organization of HA- and versican-rich pericellular matrices may faciliatate migration and mitosis by diminishing cell surface adhesivity and affecting cell shape through steric exclusion and the viscous properties of HA proteoglycan gels.
Synonyms	AsTP3; CBP1; CBP2; gp46; HSP47; OI10; PIG14; PPROM; RA-A47; SERPINH2
Note	Detects a 47kDa protein
Reference Data
Protein Families	Druggable Genome

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