CENPA Mouse Monoclonal Antibody [Clone ID: 5A7-2E11]

Specifications

Product Data
Clone Name	5A7-2E11
Applications	WB
Recommend Dilution	WB: 1:1000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide corresponding to a portion of human CENP-A.
Isotype	IgG1
Formulation	PBS, 50% glycerol
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	centromere protein A
Database Link	NP_001800 Entrez Gene 1058 Human UniProt ID P49450
Background	A replicated chromosome includes two kinetochores that control chromosome segregation during mitosis. The Centromere Protein-A, CENP-A, is a Histone H3-like protein that contains a C-terminal H3-like domain, which is required for centromere localization of CENP-A, and an antigenic N-terminal domain.CENP-A, originally isolated from HeLa cells, is essential for kinetochore targeting of CENP-C. In the presence of DNA CENP-A forms an octa-meric complex with histones H4, H2A, H2B. CENP-A specifically localizes to active centromeres and is a component of specializedcentromeric nucleosomes, on which kinetochores are assembled. CENP-A is essential for nucleosomal packaging of centromeric DNA at interphase and functions as a centromere formation marker on the chromosome.
Synonyms	CenH3; CENP-A
Note	Detects ~18kDa. Recognizes Human CENP-A
Reference Data

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