Caspr2 (CNTNAP2) Mouse Monoclonal Antibody [Clone ID: S67-25]

Specifications

Product Data
Clone Name	S67-25
Applications	IHC, WB
Recommend Dilution	WB: 1ug/ml, IHC: 0.1-1ug/ml, IF: 1-10ug/ml
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Fusion protein 96-1265 (extracellular domain) of human CASPR2
Isotype	IgG2a
Formulation	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	contactin associated protein-like 2
Database Link	NP_054860 Entrez Gene 66797 MouseEntrez Gene 500105 RatEntrez Gene 26047 Human UniProt ID Q9UHC6
Background	Caspr (contactin-associated protein) is a part of the neurexin family. It lies in the paranodal section of the myelin sheath. Its role is for myelin sheath attachment along with contactin in a cis-complex . Caspr and Caspr2 regulate the formation of distinct axonal domains around the nodes of Ranvier. Caspr is required for the generation of a membrane barrier at the paranodal junction, whereas Caspr serves as a membrane scaffold that clusters Kv1 channels at the juxtaparanodal region. Both interact with protein 4.1B .
Synonyms	AUTS15; CASPR2; CDFE; NRXN4; PTHSL1
Note	Detects ~180kDa. No cross reactivity to CASPR/Paranodin
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs)
Shipping	Blue Ice

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