TFEB Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC
Recommend Dilution	IHC: 2.5 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Rabbit polyclonal TFEB antibody was raised against a 16 amino acid peptide near the carboxy terminus of human TFEB.
Isotype	IgG
Formulation	TFEB antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	TFEB antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	transcription factor EB
Database Link	NP_009093 Entrez Gene 7942 Human UniProt ID P19484
Background	The Transcription factor EB (TFEB) is a member in the basic helix-loop-helix leucine zipper superfamily of transcription factors that is translocated in a subset of renal tumors (1,2). Recent studies have shown that lysosomal biogenesis is regulated by TFEB (3), which is in turn regulated by the mammalian target of rapamycin (mTOR) complex 1 (4). Other evidence suggests that TFEB coordinates the major steps of the autophagic pathway by driving the expression of autophagy and lysosomal genes (5).
Synonyms	ALPHATFEB; BHLHE35; TCFEB
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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