DELE1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL, IF: 20 ug/mL
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	DELE antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human DELE.
Isotype	IgG
Formulation	DELE Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	DELE Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	KIAA0141
Database Link	NP_055588 Entrez Gene 307480 RatEntrez Gene 9812 Human UniProt ID Q14154
Background	DELE Antibody: DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-α and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-α, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.
Synonyms	DELE
Reference Data

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