Kallikrein 4 (KLK4) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLK4 antibody was raised against a 15 amino acid peptide near the center of human KLK4.
Isotype	IgG
Formulation	KLK4 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	KLK4 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 28 kDa; Observed: 31 kDa
Gene Name	kallikrein related peptidase 4
Database Link	NP_004908 Entrez Gene 9622 Human UniProt ID Q9Y5K2
Background	Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes having diverse physiological functions (1). Kallikrein 4 (KLK4), also known as prostase or EMSP1 (enamel matrix serine protease 1), contains one peptidase S1 domain and the expression in prostate is regulated by hormone (1,2). Many kallikreins are implicated in carcinogenesis and have potential as novel cancer and other disease biomarkers (3). KLK4 may have additional roles such as functioning as one of the two major enamel proteases identified that process enamel matrix proteins. Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) (4).
Synonyms	AI2A1; ARM1; EMSP; EMSP1; kallikrein; KLK-L1; PRSS17; PSTS
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane

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