IL1F10 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	IL-1F10 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human IL-1F10.
Isotype	IgG
Formulation	IL-1F10 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	IL-1F10 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 17 kDa; Observed: 20 kDa
Gene Name	interleukin 1 family member 10 (theta)
Database Link	NP_775184 Entrez Gene 84639 Human UniProt ID Q8WWZ1
Background	The cytokine IL-1 is responsible for initiating a variety of activities through the activation of transcription factors, NF-kappa B and AP-1, thereby promoting host response to injury or infection (1). IL-1F10 (Interleukin-1 family member 10), also known as FIL1T, IL1HY2 or FKSG75, is highly expressed in the skin, spleen and proliferating B-cells of the tonsil (2). IL-1F10 binds soluble IL-1 receptor type 1, and is one of nine Interleukin 1 families clustered on chromosome 2, where it is thought to participate in the regulation of adapted and innate immune responses (3). IL-1F10 and IL-1RN polymorphisms may play an important role in the susceptibility to developing rheumatoid arthritis (4).
Synonyms	FIL1-theta; FKSG75; IL-1HY2; IL-38; IL1-theta; IL1HY2
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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