PHC3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	PHC3 antibody was raised against a 19 amino acid peptide near the amino terminus of human PHC3.
Isotype	IgG
Formulation	PHC3 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	PHC3 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 109 kDa; Observed: 120 kDa
Gene Name	polyhomeotic homolog 3
Database Link	NP_079223 Entrez Gene 241915 MouseEntrez Gene 310258 RatEntrez Gene 80012 Human UniProt ID Q8NDX5
Background	Polycomb group (PcG) proteins assemble into multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes throughout development (1). PHC3 (Polyhomeotic-like protein 3), also known as Early development regulatory protein 3, is a 983 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex (2). PRC1 complex acts via chromatin remodeling and modification of histones. PHC3 contains 1 FCS-type zinc finger and SAM (sterile alpha motif) domain (2-3). PHC 3 has been regarded as a candidate tumor suppressor of osteosarcoma (4).
Synonyms	EDR3; HPH3
Reference Data

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