GRK6 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	GRK6 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human GRK6.
Isotype	IgG
Formulation	GRK6 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	GRK6 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 63 kDa; Observed: 63 kDa
Gene Name	G protein-coupled receptor kinase 6
Database Link	NP_001004106 Entrez Gene 2870 Human UniProt ID P43250
Background	The G protein–coupled receptor kinases (GRKs) are a versatile family of kinases that play a critical role in cancer metastasis through their regulation of G-protein coupled receptors (GPCRs) involved in growth factor mediated cell migration (1,2). Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state (1). GRK6 is one of 7 members of the GRK serine/threonine kinase subfamily, which has been shown to modulate the Wnt signaling pathway via phosphorylation of LRP6 (3,4), and the insulin-like growth factor signaling pathway (4). GRK6 may also play a role in immune system function (5).
Synonyms	GPRK6
Reference Data

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