Arrestin C (ARR3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 0.5 - 1 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	ARR3 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human ARR3.
Isotype	IgG
Formulation	ARR3 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	ARR3 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 43 kDa; Observed: 47 kDa
Gene Name	arrestin 3 retinal (X-arrestin)
Database Link	NP_004303 Entrez Gene 170735 MouseEntrez Gene 171107 RatEntrez Gene 407 Human UniProt ID P36575
Background	Arrestin 3 (ARR3) belongs to the Arrestin family of proteins that function as negative regulators of G protein-coupled receptor (GPCR) signaling (1,2). ARR3 binds the c-Jun N-terminal kinase 3 (JNK3) and scaffolds the apoptosis signal-regulating kinase 1 (ASK1)-MAPK kinase4-JNK3 cascade in a receptor-independent fashion, promoting JNK3 phosphorylation (3,4). ARR3 also mediates the internalization of the C-C chemokine receptor CCR7 upon the binding of its ligand CCL19, but not CCL21, suggesting that it helps mediate CCR7 receptor desensitization (5).
Synonyms	ARRX
Reference Data
Protein Families	Druggable Genome

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