IKK beta (IKBKB) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB 1:500 - 1:2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide of human IKBKB
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Database Link	NP_001547 Entrez Gene 16150 MouseEntrez Gene 84351 RatEntrez Gene 3551 Human UniProt ID O14920
Background	The NF-?B/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory I?B proteins. Most agents that activate NF-?B do so through a common pathway based on phosphorylation-induced, proteasome-mediated degradation of I?B. The key regulatory step in this pathway involves activation of a high molecular weight I?B kinase (IKK) complex whose catalysis is generally carried out by three tightly associated IKK subunits. IKKa and IKKβ serve as the catalytic subunits of the kinase and IKK? serves as the regulatory subunit. Activation of IKK depends upon phosphorylation at Ser177 and Ser181 in the activation loop of IKKβ (Ser176 and Ser180 in IKKa), which causes conformational changes, resulting in kinase activation.
Synonyms	IKK-beta; IKK2; IKKB; IMD15; NFKBIKB
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Transcription Factors
Protein Pathways	Acute myeloid leukemia, Adipocytokine signaling pathway, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Cytosolic DNA-sensing pathway, Epithelial cell signaling in Helicobacter pylori infection, Insulin signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Pancreatic cancer, Pathways in cancer, Prostate cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway, Type II diabetes mellitus

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